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2022 Mercedes-Benz E450 review

Research, photos, specs, and expertise

Mercedes-Benz E450 highlights

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Mileage (EPA estimate)

21 city, 28 highway, 24 combined

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All Mercedes-Benz E450 years

What is new for the 2022 Mercedes-Benz E450?

  • E450 trims have been upgraded with Heated Steering Wheel as standard equipment this year.

2022 Mercedes-Benz E450 trims

Curious how Mercedes-Benz E450 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities

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* Price excludes taxes, title, registration, and fees. Applicable transfer fees are due in advance of vehicle delivery and are separate from sales transactions.

We hope you found this information helpful. This content is intended to inform and is not meant to indicate that a particular vehicle is currently available or recommended for you.​

Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.

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