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2022 Mercedes-Benz S500 review

Research, photos, specs, and expertise

Mercedes-Benz S500 highlights

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Mileage (EPA estimate)

21 city, 30 highway, 24 combined

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All Mercedes-Benz S500 years

What is new for the 2022 Mercedes-Benz S500?

  • S500 trims have been upgraded with 20 Inch Plus Wheels and CD Audio as standard equipment this year.
  • DVD Video System features are now available as options on select trims.

2022 Mercedes-Benz S500 trims

Curious how Mercedes-Benz S500 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities

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Ratings & reliability

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2022 Mercedes-Benz S500 FAQ

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* Price excludes taxes, title, registration, and fees. Applicable transfer fees are due in advance of vehicle delivery and are separate from sales transactions.

We hope you found this information helpful. This content is intended to inform and is not meant to indicate that a particular vehicle is currently available or recommended for you.​

Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.

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