This is my second diesel truck, first used, and I am very pleased. I have heard all the horror stories about the 6.0L powerstroke, and it does concern me, that's why we decided to purchase the extended warranty. I did have to get a valve cover gasket and a rear end gasket replaced, but both were done within the 30 day warranty Carmax gives. The truck, however, was put to the test within the first month of me owning it. After the first week, I made a 1,200 mile trip, and the pulled my 10,500 lb camper 700 miles after I had it only 3 weeks, then made another 800 mile trip, dry. Needless to say, it is performing the tasks in which I bought it to do!!
Completely happy with the truck. Gas mileage as mentioned by others is around 15mpg with a combination of city and freeway. Towing no problem, don't even know my trailer (8000 lbs.) is even back there and the fuel mileage is the same. Plenty of room! Back seat area is huge. Wish there was some power outlets in the back for the kids stuff (It's there on the 2008) but overall the fit and finish is good (not up to european cars, but good). It rides smooth and is very quiet can't hear the diesel once moving. I have the short bed and it's a bear to park though. Considered a long bed and I'm very happy that I didn't get the extra length, especially when trying to get in any parking stall. I have the Lariat package, leather, Captians Seats, wood grain, etc. Very basic for the upgrade, but it's a truck and seems just stylish enough for my tastes. Power adjustable pedals that I though would be an assume feature have been so, so. Really no consernable difference for my height (6'2") when I adjust them up or down. I also have the built in brake controller and the tow/haul transmisson. These are excellent features and would not pass this up if your doing any towing. 23,000 miles so far and no problems.
Overall, I am very pleased with the 2006 Ford F-250. I did find, however, that the mileage rating for this vehicle was overstated.I have yet to get over 14 mpg with this vehicle.I expect to get even less with my truck camper installed.