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2021 Mercedes-Benz GLS580 review

Research, photos, specs, and expertise

Mercedes-Benz GLS580 highlights

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Mileage (EPA estimate)

16 city, 21 highway, 18 combined

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All Mercedes-Benz GLS580 years

What is new for the 2021 Mercedes-Benz GLS580?

  • GLS580 trims have been upgraded with Rear Air Conditioning as standard equipment this year.
  • Run Flat Tires features are now available as options on select trims.

2021 Mercedes-Benz GLS580 trims

Curious how Mercedes-Benz GLS580 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities

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* Price excludes taxes, title, registration, and fees. Applicable transfer fees are due in advance of vehicle delivery and are separate from sales transactions.

We hope you found this information helpful. This content is intended to inform and is not meant to indicate that a particular vehicle is currently available or recommended for you.​

Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.

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