2021 Mercedes-Benz E350 review
Mercedes-Benz E350 highlights
Customer rating
Mileage (EPA estimate)
22 city, 30 highway, 25 combined
Pricing for current inventory
(no current inventory)
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All Mercedes-Benz E350 years
What is new for the 2021 Mercedes-Benz E350?
- E350 trims have been upgraded with Front Seat Heaters and Run Flat Tires as standard equipment this year.
- Rear Seat Heaters features are now available as options on select trims.
2021 Mercedes-Benz E350 trims
Curious how Mercedes-Benz E350 trims differ? Use our side-by-side vehicle comparison to see the differences and similaritiesBase:
- 255-hp, 273-lb-ft of torque 2.0L
- Front Seat Heaters
- Seat Massagers
- Sunroofs
- Memory Seats
- Power Seats
- Leatherette Seats
- Smart Key
- Rear View Camera
- View our Mercedes-Benz E350 inventory
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Ratings & reliability
RepairPal gave the Mercedes-Benz E350 an overall reliability rating of 3.5 out of 5 stars, which RepairPal describes as Above Average. This rating ranks Mercedes-Benz E350 10th out of 48 among Luxury Fullsize Cars.
View RepairPal's full rating of the Mercedes-Benz E3502021 Mercedes-Benz E350 FAQ
The 2021 Mercedes-Benz E350 offers 22 MPG City and 31 MPG Highway. It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency.
The Mercedes-Benz E350 received a rating of 3.5 out of 5 stars from RepairPal, which RepairPal describes as Above Average. This rating ranks the Mercedes-Benz E350 as 9 out of 48 among Luxury Fullsize Car
The 2021 Mercedes-Benz E350 has received an average 5.0 out of 5 stars from our customers. If you're in the market for a 2021 Mercedes-Benz E350, check out reviews from customers just like you. 2021 Mercedes-Benz E350 Reviews.
Here is what's new for the 2021 Mercedes-Benz E350:
- Front Seat Heaters
- Seat Massagers
- Heated Mirrors
- Run Flat Tires
- Rear Seat Heaters
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We hope you found this information helpful. This content is intended to inform and is not meant to indicate that a particular vehicle is currently available or recommended for you.
Statements of fuel economy or EV range are based on EPA and other third-party estimates for vehicles when new. Fuel economy and EV range will degrade with time and vary based on age, driving conditions, vehicle history, and other conditions. See fueleconomy.gov for more info.
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We make every effort to provide accurate information, but please verify before purchasing.

