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Used Mercedes-Benz E350 for Sale

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About the Mercedes-Benz E350

Vehicle Summary

Want to turn heads in a stylish and luxurious car? The Mercedes-Benz E-Class may be a great place to start; this midsize luxury vehicle can seat up to five passengers in its sedan and wagon body styles, although it is also offered in four-passenger coupe and convertible versions.

The E-Class is offered in a variety of trim configurations throughout its last two generations of production (2009-2016 and 2017-2019)—but if you're looking for a well-appointed trim with a powerful standard engine, you'll want to check out the E350. This trim comes with a 3.5L V6 engine, plus generous features like an eight-speaker sound system and simulated-leather upholstery on its 2016 model so you can ride in style and comfort.

Unless otherwise noted, information relating to these featured vehicles comes from third-party sources, including manufacturer information. Product and company names may be trademarks™ or registered® trademarks of third-party entities. Use of them does not imply any affiliation with or endorsement by these entities.


Q: Does Mercedes-Benz still make the E350?

A: Yes. The E350 was briefly discontinued (replaced by the E300) for the E-Class fifth generation (2017-2019). However, the E350 trim is being brought back for the 2020 model year.

Q: What engine is in a Mercedes E350?

A: Engine configurations can vary by model year. However, the 2016 Mercedes-Benz E350 comes with a 3.5L V6 engine at 302 hp.

Q: What is the difference between a Mercedes E300 and E350?

A: The E300 temporarily replaced the E350 trim on the Mercedes-Benz E-Class from 2017-2019; the main difference is that it features a turbocharged 2.0L four-cylinder engine at 241 hp on its 2017 model, compared to the 3.5L V6 engine rated at 302 hp on the 2016 E350.

Q: What is E350 BlueTEC®?

A: The E350 BlueTEC is an engine option offered on some earlier model years of the Mercedes-Benz E-Class (including 2013); specifically, BlueTEC engines are designed to optimize fuel injection pressure and reduce emissions.

CarMax Rankings

Mercedes-Benz E350 Trim Configurations

The Mercedes-Benz E350 was offered as part of midsize E-Class series for many years, although 2014-2016 are the most recent. During this time, the E350 is characterized by a 3.5L V6 engine at 302 hp, a seven-speed automatic transmission, and rear-wheel drive.

For the 2014 model year, the E350 is offered in sedan, coupe, convertible, and wagon body styles. Beginning with 2015, however, the E350 is available exclusively in sedan and wagon styles.

For each model year, the E350 sedan and wagon are also available with Luxury and Sport sub trims. The following sub trim features are based specifically on the 2016 model year.

Every 2016 E350 model comes with standard features that include:

  • Adaptive suspension dampers
  • Automatic dual-zone climate control
  • Simulated-leather upholstery
  • Eight-speaker sound system
  • 10-way power front seats with memory functions


  • 17-inch alloy wheels
  • Mercedes-Benz hood ornament


  • Two-bar front grille
  • Sport-tuned suspension
  • Upgraded wheels

Reliability Research

Above Average

RepairPal gave the Mercedes-Benz E350 an overall reliability rating of 3.5 out of 5 stars, which RepairPal describes as Above Average. This rating ranks the Mercedes-Benz E350 12th out of 30 among luxury fullsize cars.

  • Cost RepairPal reports that the average total annual cost for repairs and maintenance on a Mercedes-Benz E350 is $788, compared to an average of $920 for luxury fullsize cars and $719 for all the vehicles RepairPal considered in its dataset.
  • Frequency According to RepairPal, Mercedes-Benz E350 owners bring their vehicles into a repair shop for unscheduled repairs an average of 0.6 times per year, compared to an average of 0.8 times for luxury fullsize cars and 0.5 times for all the vehicle models RepairPal considered in its dataset.
  • Severity RepairPal reported that the probability of a repair being a severe or major issue is 13% for the Mercedes-Benz E350, compared to an average of 15% for luxury fullsize cars and 13% for all the vehicles RepairPal considered in its dataset.

RepairPal Reliability Ratings are based on the actual cost, frequency, and severity of unscheduled repairs and maintenance on make/model data for select 2010-2019 vehicles. The reliability of a specific vehicle may vary depending on its maintenance and driving history, model year, trim, and features.

*RepairPal Reliability Ratings are provided by RepairPal and CarMax is not responsible for their accuracy. These ratings are based on RepairPal Reliability data as of 12/31/2018. Learn more.


Reviews for Mercedes-Benz E350

Overall Rating

4.6 out of 5(231 reviews)

Fuel Efficient Diesel Mercedes

It is a very nice car for the money. It is fuel efficient and diesel is also cheaper than premium gasoline which the regular E350 needs. Handles and rides very well also. One downside is the run-flat tires that this car has which severely impacts road noise. In place of the spare tire, it has a AdBlue fluid tank which has to be replaced regularly so regular maintenance costs are slightly higher than gasoline models.

- Daniel Park, 2013 Mercedes-Benz E350

Best vehicle I've owned to date...

I did my research on luxury sedans before deciding on the Mercedes-Benz E350 over other cars in the category like the Audi A6, Cadillac CTS, and BMW 335i. After driving these modesl, my decision to purchase the E350 was simply that it brings the entire package I was looking for (performance, interior amenities, safety, and reliability) in a design that is strikingly refined yet not over the top. The ride is tremendous and the interior is extremely comfortable for my size (6'2" 220lbs).

- Craig Piotrowski, 2013 Mercedes-Benz E350

Excellent mid-size car.

The 2012 MB E-Class is a fantastic car. It is a true mid-size (same basic size as an Accord or Camry) but is much quieter. The 6 cylinder has plenty of power without the need for a turbo. It does require premium gas, which I understand is more for the catalytic converter than for the anti-knock feature, but I have gotten almost 30 mpg on the highway on mostly flat highways. In the hills of Western Maryland/West Virginia, considerably less. The trunk is a good size and the rear seat folds down for more storage. I have the 60/40 split seat which is very nice. The sound/nav/instrument system is extensive. It took several days of reading and playing to get the hand of everything. Not that it is that complicated, just a lot of stuff.

- Bruce Clasing, 2012 Mercedes-Benz E350

This price does not include tax, title, and tags. Additional fees may also apply depending on the state of purchase.