The most fuel-efficient Buick LaCrosse is the 2015 Buick LaCrosse Leather which gets 25 MPG City and 36 MPG Highway.
It is important to remember factors such as driving style, weather conditions, and the use of features such as Eco mode can impact fuel efficiency. Fuel economy figures are based on EPA estimates for when vehicle sold as new. Fuel economy may vary for reasons like driving conditions and vehicle history. Unless specified, figures are for vehicles equipped with an automatic transmission. See fueleconomy.gov.