2021 Lexus IS 350

Research, photos, specs, and expertise

Lexus IS 350 highlights

Customer rating

Mileage (EPA estimate)

19 city, 26 highway, 22 combined

Pricing for current inventory

(no current inventory)


All Lexus IS 350 years

New for 2021

  • The Base trim has been discontinued for 2021.
  • IS 350 trims have been upgraded with Heated Steering Wheel, Apple CarPlay, Android Auto, and Pioneer Sound System as standard equipment this year.
  • MACH Audio System features are now available as options on select trims.

Explore Lexus IS 350 details

F-Sport 2WD 4D Sedan

Standard Features

  • A/C Seat(s)
  • ABS Brakes
  • Air Conditioning
  • Alloy Wheels
  • AM/FM Stereo
  • Android Auto
  • Apple CarPlay
  • Automated Cruise Control
  • Automatic Transmission
  • Auxiliary Audio Input
  • Blind Spot Monitor
  • Bluetooth Technology
  • Front Seat Heaters
  • Heated Steering Wheel
  • Lane Departure Warning
  • Leatherette Seats
  • Overhead Airbags
  • Pioneer Sound System
  • Power Locks
  • Power Mirrors
  • Power Seat(s)
  • Power Windows
  • Rear Defroster
  • Rear Spoiler
  • Rear View Camera
  • Satellite Radio Ready
  • Side Airbags
  • Smart Key
  • Traction Control
  • Blind Spot Monitor
  • CD Audio
  • Heated Steering Wheel
  • MACH Audio System
  • Mark Levinson Sound
  • Memory Seat(s)
  • Navigation System
  • Parking Sensors
  • Rear Spoiler
  • Rear Sunshade
  • Sunroof(s)

Drive Wheels

Rear Wheel Drive (2WD)

Engine size




Torque (ft-lbs)


Engine type


Fuel capacity




Overall length






Leg room

F 44.8"/R 32.2"

Head room

F 38.2"/R 36.9"

Front tires


Rear tires


Seating capacity




5 reasons to buy the 2021 Lexus IS 350

1. Potent engine

Powered by a potent engine and equipped with a special sports suspension, the 2021 Lexus IS 350 offers a dynamic performance and provides an exciting driving experience. It comes standard with a naturally aspirated 3.5L V6 engine with 311 hp and 280 lb-ft of torque and is offered with either rear- or all-wheel drive. According to the manufacturer, with this engine and with rear-wheel drive, the IS 350 can go from zero to 60 mph in 5.6 seconds, and reach a top speed of 143 mph. Additionally, the nimble handling and the responsive steering help make for truly athletic performance.

2. User-friendly tech features

In addition to performance, the 2021 Lexus IS 350 has a lot to offer when it comes to technology, as well. With the series of connectivity and entertainment features that are part of the standard equipment, passengers will always have a pleasant ride. The IS 350 comes with a user-friendly eight-inch touchscreen infotainment system with Apple CarPlay® and Android Auto integration, which can also be controlled via voice commands. A ten-speaker stereo system and Bluetooth® connectivity are also standard, as well as satellite radio and two USB ports.

3. Standard driver-assist features

For increased confidence and easier maneuverability while on the road, the 2021 Lexus IS 350 is fitted with several driver-assist systems. For starters, it comes standard with blind-spot monitoring and rear cross-traffic alert, along with forward collision warning and forward automatic emergency braking. Lane departure warning, lane-keep assist, and pedestrian and cyclist detection are also standard.

4. Balanced performance

The 2021 Lexus IS 350 is also a practical and convenient choice when it comes to fuel consumption. It balances gas mileage with its spirited performance, so if you have a long commute to work or travel long distances on the open road often, it might be a great option for you. With the 3.5L V6 engine and rear-wheel drive, the 2021 Lexus IS 350 gets an EPA-estimated 23 mpg combined.

5. Attractive design

As a bonus to the functionality, convenience, and performance of the 2021 Lexus IS 350, it also comes with an attractive exterior design. It's a good-looking car, with a few unique elements such as the mesh hourglass grille and the checkmark-shaped LED headlights, creating an imposing front end. Highlighting its sporty nature, the IS 350 is fitted with a black diffuser and a dual exhaust pipe, along with redesigned air intakes that are positioned a bit lower than its predecessors to further enhance its good looks.

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Ratings & reliability

Customer ratings


RepairPal gave the Lexus IS 350 an overall reliability rating of 4.5 out of 5 stars, which RepairPal describes as Excellent. This rating ranks Lexus IS 350 5th out of 55 among Luxury Midsize Cars.

View RepairPal's full rating of the Lexus IS 350

2021 Lexus IS 350 trims

Curious how Lexus IS 350 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities


2021 Lexus IS 350 FAQ

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