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2022 Lexus RX RX 350 front grill

Lexus RX 350

Kirk Bell, Edmunds Contributor
Kirk Bell | Edmunds Contributor
July 14, 2025

The Lexus RX 350 practically wrote the book on the luxury crossover SUV, bringing a smooth, car-like ride to the SUV format as early as 1998. It offers a pleasant driving character, functional and flexible cargo space, and a reputation for refinement. It seats five passengers in comfort and offers turbocharged four-cylinder power with three hybrid variants, all of which we cover separately. Front-wheel drive comes standard and all-wheel drive is available for all RX 350 models, with all-wheel drive standard on the hybrids.  

Explore the evolution of the Lexus RX 350

Get our expert take on used Lexus RX 350 models, or view year-by-year changes.

Fifth generation
2023 - present
No image available
$40,998 - $56,998*
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Fourth generation
2016 - 2022
No image available
$19,998 - $46,998*
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Third generation
2010 - 2015
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$16,998 - $26,998*
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2023 - present

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Fifth generation Lexus RX 350

Lexus toned down the styling of the RX 350 when it released the fifth-generation model in 2023. It still sports a version of the brand’s spindle grille, but it no longer has the excessive front overhang from the previous generation. It also got a stiffer and lighter platform, dropped the V6 engine, and offered a choice of larger touchscreens inside. 

The engine in RX 350 models is a 2.4-liter turbocharged four-cylinder that delivers impressive power and offers fuel economy as high as 25 mpg combined, according to the EPA.

The power goes to the front or all four wheels via an eight-speed automatic transmission. F Sport models get sharper handling and a sportier look.

Inside, Lexus offers a 9.8-inch or 14-inch touchscreen, as well as a 12.3-inch digital instrument cluster. This generation has only two seating rows, with the long-wheelbase seven-seater version of the last generation no longer available.

Driver-assist technology is plentiful, too, including automatic emergency braking, blind-spot monitoring, lane-keeping assistance, adaptive cruise control, and a limited hands-free system for driving at lower speeds.


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$40,998 - $56,998

Model highlights

  • 2.4-liter four-cylinder comes standard; hybrids and a plug-in hybrid available

  • 9.8-inch or 14-inch touchscreens

  • Standard 12.3-inch digital instrument cluster (added for 2025)

  • No V6 or third row available this generation

  • F Sport models have adaptive dampers

View year by year changes

2016 - 2022

No image available

Fourth generation Lexus RX 350

The fourth-generation RX 350 arrived with a longer, creased body and a “floating” roof characterized by dark accents separating the roofline from the body sides. It got larger inside and added a 12.3-inch infotainment screen that ran through a mouselike controller on the center console. 

Two powertrains were available at launch, a strong and smooth 3.5-liter V6 backed by an eight-speed automatic transmission, and a 2.5-liter four-cylinder hybrid with a pair of electric motors and an available third motor for all-wheel drive. Both powertrains offered front- or all-wheel drive. 

The RX originally seated five, but a three-row version with seven-passenger capacity called the RX L arrived for 2018. The rear seat was very small.

Adaptive cruise control, lane-keeping assistance, blind-spot monitoring, and rear cross-traffic alert were available.

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$19,998 - $46,998

Model highlights

  • Fourth-generation model grew by five inches

  • 4.3-inch-longer three-row RX L body style (added for 2018)

  • 2020 model year design refresh

  • Touchscreen, either eight or 12.3 inches, with a touchpad instead of a mouse (added for 2020)

View year by year changes

2010 - 2015

No image available

Third generation Lexus RX 350

For its third generation, the RX 350 got slightly wider, moved to larger wheels, and went to a double-wishbone rear suspension for improved ride quality and better cargo space. It largely kept its rounded, jelly-bean styling. More equipment meant a roughly 400-pound weight gain.

Under the hood, the RX still sported a smooth and powerful 3.5-liter V6, but the automatic transmission added a gear for a total of six. A hybrid model also remained in the lineup, and once again the RX was available with front- and all-wheel drive.

Inside, the RX added the Lexus Remote Touch infotainment system with a mouselike controller for its center screen. The system required some manual dexterity and looking back and forth from the center console to the dashboard screen.

Lexus gave the RX a styling update for 2013 and added the first F Sport package that year. The package included firmer suspension tuning and upgraded from a six-speed to an eight-speed automatic.

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$16,998 - $26,998

Model highlights

  • Styling refresh for 2013 model year 

  • F Sport package (added for 2013)

  • Standard rearview camera and seven-inch screen (added for 2015)

  • Six-speed automatic (added for 2010)

View year by year changes

Changes by year

Latest generation from 2023 - present

2025 Lexus RX 350

Highlights

  • New Black Line Special Edition styling package

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2024 Lexus RX 350

Highlights

  • No significant changes for 2024

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2023 Lexus RX 350

Highlights

  • Redesigned for 2023 with more restrained styling

  • V6 engine dropped

  • New turbocharged four-cylinder engine

  • Larger screens inside; clunky touchpad control went away

  • No more third row

Learn more

Previous generation from 2016 - 2022

2022 Lexus RX 350

Highlights

  • No significant changes for 2022

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2021 Lexus RX 350

Highlights

  • Blind-spot monitoring and rear cross-traffic alert became standard

  • Wireless smartphone charging newly available

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2020 Lexus RX 350

Highlights

  • Revised front and rear styling

  • Slightly sportier handling

  • New touchscreen with touchpad instead of mouse

  • Larger eight-inch or 12.3-inch touchscreens

  • Apple CarPlay® and Android Auto™ standard

  • More standard driver-assist features

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2019 Lexus RX 350

Highlights

  • Integration with Lexus Enform Connect smartphone app

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2018 Lexus RX 350

Highlights

  • New three-row RX L offered with 4.3-inch-longer body

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2017 Lexus RX 350

Highlights

  • More standard driver-assist features

  • F Sport trim offered with front-wheel drive.

Learn more

2016 Lexus RX 350

Highlights

  • Redesigned with a creased body and “floating roof” design

  • Launched with two rows of seats

  • More luxurious interior

  • More power for V6

  • More driver-assist features

  • Suspension tuned for improved handling

Learn more

Previous generation from 2010 - 2015

2015 Lexus RX 350

Highlights

  • Rearview camera and seven-inch screen became standard

  • LED headlights and foglights newly available

  • Remote Touch mouse controller revised for better ergonomics

  • New Crafted Line trim level added

Learn more

Looking for 2012 models or older?

CarMax only sells 2013 models and newer. But no matter the year, we'll happily buy your car.

Reliability

4
1
2
Excellent

RepairPal gave the Lexus RX 350 an overall reliability rating of 4.5 out of 5 stars, which RepairPal describes as Excellent. This rating ranks Lexus RX 350 3rd out of 29 among Luxury Midsize SUVs.

RepairPal reports that the average total annual cost for repairs and maintenance on a Lexus RX 350 is $408, compared to an average of $642 for Luxury Midsize SUVs and $591 for all the vehicles RepairPal considered in its dataset.

According to RepairPal, Lexus RX 350 owners bring their vehicles into a repair shop for unscheduled repairs an average of 0.8 times per year, compared to an average of 1.4 times for Luxury Midsize SUVs and 1.3 times for all the vehicles RepairPal considered in its dataset.

RepairPal reported that the probability of a repair being a severe or major issue is 6% for the Lexus RX 350, compared to an average of 13% for Luxury Midsize SUVs and 14% for all the vehicles RepairPal considered in its dataset.

Kirk Bell, Edmunds Contributor
Kirk Bell | Edmunds Contributor

Kirk Bell has been an automotive journalist since 2001, doing stints at Motor Authority, MSN Autos, and Consumer Guide. He's currently a freelance journalist with an interest in luxury and performance cars.



* Price excludes taxes, title, registration, and fees. Applicable transfer fees are due in advance of vehicle delivery and are separate from sales transactions.

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