2022 Lexus RX 350 review

Research, photos, specs, and expertise

Lexus RX 350 highlights

Customer rating


  • Six USB ports for tech lovers
  • Tow ability for a small trailer
  • Leather and soft-touch plastics in the cabin


  • Awkward trackpad controller on infotainment system
  • Some Android apps won't sync
  • F Sport trim is bouncy on older roads

Mileage (EPA estimate)

18 city, 25 highway, 21 combined

Pricing for current inventory

(no current inventory)


The 2022 Lexus RX prioritizes comfort and luxury

The 2022 Lexus RX 350 marks the end of the line for this fourth-generation model that was introduced in 2016. Over those years, it solidified its position as a comfortable and efficient alternative to the German brands, but time caught up with the RX. Besides this RX 350, there’s also a more efficient RX 450h hybrid as well as a three-row RX 350L that are reviewed separately.

There were no significant changes for the 2022 RX 350 since engineers were likely hard at work on the next-generation model. While this RX deserved praise for its high levels of overall comfort, it was held back by a very frustrating infotainment interface that technophiles could consider a deal breaker.

If you’re able to easily use that trackpad controller, perhaps the RX is the midsize luxury SUV you’ve been looking for. Otherwise, we’d steer you toward alternatives such as the BMW X3, Volvo XC60, or Mercedes-Benz GLE.

All Lexus RX 350 years

What is new for the 2022 Lexus RX 350?

  • The RX 350 is available in a new trim called the F-SPORT Handling.
  • The Performance trim has been discontinued for 2022.
  • RX 350 trims have been upgraded with Rear Air Conditioning, Rear Seat Heaters, and Rear Sunshade as standard equipment this year.
  • The Base trim now comes with Satellite Radio Ready as standard equipment.

2022 Lexus RX 350 trims

Curious how Lexus RX 350 trims differ? Use our side-by-side vehicle comparison to see the differences and similarities


  • 295-hp, 267-lb-ft of torque 3.5L
  • Rear Defroster
  • Automated Cruise Control
  • Power Seats
  • Overhead Airbags
  • Power Mirrors
  • Traction Control
  • Leatherette Seats
  • Side Airbags
  • View our Lexus RX 350 inventory


  • Includes all features available on the Base
  • 290-hp, 263-lb-ft of torque 3.5L
  • Rear Air Conditioning
  • Third Row Seat
  • Power Folding Third Row
  • View our Lexus RX 350 L inventory


F-SPORT Handling:

L Luxury:

5 reasons to buy the 2022 Lexus RX 350

What We Like

Attractive and luxurious interior: The RX 350’s interior deserves praise for its handsome styling and high-quality materials, and it remained attractive and inviting throughout this generation’s life. You’d have a tough time finding a surface that wasn’t covered in either leather or a soft-touch plastic. It’s a solid entry among entry-level luxury SUVs and competitive against more expensive models.

Comfortable ride quality: For the most part, the Lexus RX 350 is focused more on comfort than performance and that has served this SUV well for decades. The suspension ably soaks up road imperfections and greatly reduces fatigue over long distances. The F Sport, on the other hand, attempts to add some handling performance with mixed results and that negatively affects comfort. It’s too stiff and gets jittery over rough surfaces.

Wide cargo space: With 18.4 cubic feet of available cargo capacity, the RX 350 isn’t as accommodating as some rivals, but it counters that with a more usable space. The cargo area's wide opening and floor make it much easier to load bulkier and heavier objects. For more room, the rear seats fold flat with the cargo floor. The RX is also rated to tow up to 3,500 pounds, when properly equipped.

What Needs Improvement

Frustrating infotainment interface: Lexus’ trackpad infotainment controller is legendary for all the wrong reasons. It’s one of our least favorite in any vehicle ever because it’s distracting and difficult to use when you're driving. It uses a similar pad that you’d find on a laptop and moves an on-screen cursor. Unlike a laptop, though, the RX is a moving object and trying to select your desired button is incredibly frustrating. This alone can be a deal breaker for some.

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Ratings & reliability

Customer ratings


RepairPal gave the Lexus RX 350 an overall reliability rating of 4.5 out of 5 stars, which RepairPal describes as Excellent. This rating ranks Lexus RX 350 3rd out of 29 among Luxury Midsize SUVs.

View RepairPal's full rating of the Lexus RX 350

Lexus RX 350 features and specs

L 2WD 4D Sport Utility

Standard Features

  • ABS Brakes
  • Air Conditioning
  • Alloy Wheels
  • AM/FM Stereo
  • Automated Cruise Control
  • Automatic Transmission
  • Auxiliary Audio Input
  • Blind Spot Monitor
  • Bluetooth Technology
  • CD Audio
  • Lane Departure Warning
  • Leatherette Seats
  • Overhead Airbags
  • Power Folding Third Row
  • Power Hatch/Deck Lid
  • Power Locks
  • Power Mirrors
  • Power Seat(s)
  • Power Windows
  • Rear Air Conditioning
  • Rear Defroster
  • Rear View Camera
  • Remote Start
  • Satellite Radio Ready
  • Side Airbags
  • Smart Key
  • Third Row Seat
  • Traction Control
  • 20 Inch Plus Wheels
  • A/C Seat(s)
  • Android Auto
  • Apple CarPlay
  • Front Seat Heaters
  • Full Roof Rack
  • Head Up Display
  • Heated Steering Wheel
  • Leatherette Seats
  • Mark Levinson Sound
  • Memory Seat(s)
  • Navigation System
  • Parking Sensors
  • Quad Seats
  • Rear View Camera
  • Running Boards
  • Sunroof(s)
  • Tow Hitch

Drive Wheels

Front Wheel Drive (2WD)

Engine size




Torque (ft-lbs)


Engine type


Fuel capacity




Overall length






Leg room

F 41.4"/M 30.9"/R 23.5"

Head room

F 39.8"/M 38.5"/R 34.8"

Front tires


Rear tires


Seating capacity




2022 Lexus RX 350 FAQ

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